Rare Case Report of Adult T-Cell Leukemia / Lymphoma (ATLL), in the City of Macau- Rio Grande Do Norte; Brazil

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Adult T-cell leukemia/lymphoma (ATLL)

Pathogenesis of the disease: ATLL is associated with HTLV-1 infection of the tumour clone in 100% of the cases. The interval between HTLV-1 infection and the onset of lymphoma is long (10-40 years) and only <5% of infected people actually develops the disease. HTLV-1 produces a trans-regulatory protein (Tax) inducing interleukin-2 (IL-2) and IL-2 receptor expression and consequent polyclonal CD...

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Universidade Federal Do Rio Grande Do Norte

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ژورنال

عنوان ژورنال: Blood

سال: 2020

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2020-143346